Chronic Obstructive Pulmonary Disease
Table of Contents
Metadata
| Name | Chronic Obstructive Pulmonary Disease |
| Type | Disease or Syndrome |
| Group | Respiratory |
| Data Sources | Clinical Practice Research DatallinkHospital Episode StatisticsOffice of National Statistics mortality |
| Clinical Terminologies | Read, ICD-10, ICD-9, OPCS-4 |
| Validation | cross-source, prognosis |
| Valid Event Data Range | 01/01/1999 - 01/07/2016 |
| Sex | Female/Male |
| Authors | Kuan, V; Denaxas, S; Gonzalez-Izquierdo, A; Direk, K; Bhatti, O; Husain, S; Sutaria, S; Hingorani, M; Nitsch, D; Parisinos, C; Lumbers, T; Mathur, R; Sofat, R; Casas, J; Wong, I; Hemingway, H; Hingorani, A; |
| Agreement Date | 20 May 2019 |
| Modified Date | 20 May 2019 |
| Version | Revision 1 |
Primary Care
In the Clinical Practice Research Datalink (CPRD, primary care data) we ascertained Chronic Obstructive Pulmonary Disease cases by searching for Read terms related to an Chronic Obstructive Pulmonary Disease diagnosis or evidence of endovascular/transluminal procedures related to the emergency repair of an aneurysmal segment of the aorta.
| Readcode | Medcode | ReadcodeDescr |
|---|---|---|
| 14B3.12 | 103494 | History of chronic obstructive pulmonary disease |
| H310000 | 15626 | Chronic catarrhal bronchitis |
| H310.00 | 25603 | Simple chronic bronchitis |
| H310z00 | 61118 | Simple chronic bronchitis NOS |
| H311000 | 40159 | Purulent chronic bronchitis |
| H311100 | 37959 | Fetid chronic bronchitis |
| H311.00 | 11150 | Mucopurulent chronic bronchitis |
| H311z00 | 61513 | Mucopurulent chronic bronchitis NOS |
| H312000 | 5798 | Chronic asthmatic bronchitis |
| H312011 | 5909 | Chronic wheezy bronchitis |
| H312100 | 14798 | Emphysematous bronchitis |
| H312200 | 1446 | Acute exacerbation of chronic obstructive airways disease |
| H312300 | 26125 | Bronchiolitis obliterans |
| H312.00 | 27819 | Obstructive chronic bronchitis |
| H312z00 | 44525 | Obstructive chronic bronchitis NOS |
| H313.00 | 24248 | Mixed simple and mucopurulent chronic bronchitis |
| H31..00 | 3243 | Chronic bronchitis |
| H31y100 | 45089 | Chronic tracheobronchitis |
| H31y.00 | 66043 | Other chronic bronchitis |
| H31yz00 | 68066 | Other chronic bronchitis NOS |
| H31z.00 | 15157 | Chronic bronchitis NOS |
| H320000 | 56860 | Segmental bullous emphysema |
| H320100 | 68662 | Zonal bullous emphysema |
| H320200 | 60188 | Giant bullous emphysema |
| H320300 | 99536 | Bullous emphysema with collapse |
| H320.00 | 26306 | Chronic bullous emphysema |
| H320z00 | 23492 | Chronic bullous emphysema NOS |
| H321.00 | 46578 | Panlobular emphysema |
| H322.00 | 10980 | Centrilobular emphysema |
| H32..00 | 794 | Emphysema |
| H32y000 | 92955 | Acute vesicular emphysema |
| H32y100 | 70787 | Atrophic (senile) emphysema |
| H32y111 | 59263 | Acute interstitial emphysema |
| H32y200 | 63479 | MacLeod's unilateral emphysema |
| H32y.00 | 40788 | Other emphysema |
| H32yz00 | 16410 | Other emphysema NOS |
| H32z.00 | 33450 | Emphysema NOS |
| H36..00 | 10863 | Mild chronic obstructive pulmonary disease |
| H37..00 | 10802 | Moderate chronic obstructive pulmonary disease |
| H38..00 | 9876 | Severe chronic obstructive pulmonary disease |
| H39..00 | 93568 | Very severe chronic obstructive pulmonary disease |
| H3A..00 | 104608 | End stage chronic obstructive airways disease |
| H3...00 | 1001 | Chronic obstructive pulmonary disease |
| H3...11 | 998 | Chronic obstructive airways disease |
| H3y0.00 | 21061 | Chronic obstruct pulmonary dis with acute lower resp infectn |
| H3y1.00 | 7884 | Chron obstruct pulmonary dis wth acute exacerbation, unspec |
| H3y..00 | 12166 | Other specified chronic obstructive airways disease |
| H3y..11 | 67040 | Other specified chronic obstructive pulmonary disease |
| H3z..00 | 5710 | Chronic obstructive airways disease NOS |
| H3z..11 | 37247 | Chronic obstructive pulmonary disease NOS |
| H464000 | 64721 | Chronic emphysema due to chemical fumes |
| H464100 | 63216 | Obliterative bronchiolitis due to chemical fumes |
| H583200 | 106650 | Eosinophilic bronchitis |
| Hyu3000 | 66058 | [X]Other emphysema |
| Hyu3100 | 65733 | [X]Other specified chronic obstructive pulmonary disease |
Read terms are hierarhically organized in top-level chapters i.e. chapter G….00 is related to Circulatory System Diseases and sub-headings i.e. heading G2…00 is related to Hypertensive Heart Disease while G3…00 is related to Ischaemic Heart Disease.
Secondary Care
In Hospital Episode Statistics (HES, hospital admission data) we used ICD-10 terms (see below) for Chronic Obstructive Pulmonary Disease diagnosis when marked as the primary diagnosis i.e. the main condition treated or investigated during the relevant episode of healthcare. We used the date of admission to hospital as the date of the event. We additionally searched for OPCS-4 terms indicating the emergency repair of an aneurysmal segment of the aorta.
| ICD10code | ICD10codeDescr |
|---|---|
| J40 | Bronchitis, not specified as acute or chronic |
| J41 | Simple and mucopurulent chronic bronchitis |
| J42 | Unspecified chronic bronchitis |
| J43 | Emphysema |
| J44 | Other chronic obstructive pulmonary disease |
Implementation
Combining evidence across sources to define and date phenotypes
At the specified date, a patient is defined as having had COPD IF they meet the criteria for any of the following on or before the specified date. The earliest date on which the individual meets any of the following criteria on or before the specified date is defined as the first event date: Primary care 1. COPD diagnosis or history of diagnosis during a consultation OR Secondary care (ICD10) 1. ALL diagnoses of COPD or history of diagnosis during a hospitalization
Publications
- Kuan V., Denaxas S., Gonzalez-Izquierdo A. et al. A chronological map of 308 physical and mental health conditions from 4 million individuals in the National Health Service published in the Lancet Digital Health - DOI 10.1016/S2589-7500(19)30012-3