Table of Contents


Name Chronic Obstructive Pulmonary Disease
Type Disease or Syndrome
Group Respiratory
Data Sources Clinical Practice Research DatallinkHospital Episode StatisticsOffice of National Statistics mortality
Clinical Terminologies Read, ICD-10, ICD-9, OPCS-4
Validation cross-source, prognosis
Valid Event Data Range 01/01/1999 - 01/07/2016
Sex Female/Male
Authors Kuan, V; Denaxas, S; Gonzalez-Izquierdo, A; Direk, K; Bhatti, O; Husain, S; Sutaria, S; Hingorani, M; Nitsch, D; Parisinos, C; Lumbers, T; Mathur, R; Sofat, R; Casas, J; Wong, I; Hemingway, H; Hingorani, A;
Agreement Date 20 May 2019
Modified Date 20 May 2019
Version Revision 1

Primary Care

In the Clinical Practice Research Datalink (CPRD, primary care data) we ascertained Chronic Obstructive Pulmonary Disease cases by searching for Read terms related to an Chronic Obstructive Pulmonary Disease diagnosis or evidence of endovascular/transluminal procedures related to the emergency repair of an aneurysmal segment of the aorta.

Readcode Medcode ReadcodeDescr
14B3.12 103494 History of chronic obstructive pulmonary disease
H310000 15626 Chronic catarrhal bronchitis
H310.00 25603 Simple chronic bronchitis
H310z00 61118 Simple chronic bronchitis NOS
H311000 40159 Purulent chronic bronchitis
H311100 37959 Fetid chronic bronchitis
H311.00 11150 Mucopurulent chronic bronchitis
H311z00 61513 Mucopurulent chronic bronchitis NOS
H312000 5798 Chronic asthmatic bronchitis
H312011 5909 Chronic wheezy bronchitis
H312100 14798 Emphysematous bronchitis
H312200 1446 Acute exacerbation of chronic obstructive airways disease
H312300 26125 Bronchiolitis obliterans
H312.00 27819 Obstructive chronic bronchitis
H312z00 44525 Obstructive chronic bronchitis NOS
H313.00 24248 Mixed simple and mucopurulent chronic bronchitis
H31..00 3243 Chronic bronchitis
H31y100 45089 Chronic tracheobronchitis
H31y.00 66043 Other chronic bronchitis
H31yz00 68066 Other chronic bronchitis NOS
H31z.00 15157 Chronic bronchitis NOS
H320000 56860 Segmental bullous emphysema
H320100 68662 Zonal bullous emphysema
H320200 60188 Giant bullous emphysema
H320300 99536 Bullous emphysema with collapse
H320.00 26306 Chronic bullous emphysema
H320z00 23492 Chronic bullous emphysema NOS
H321.00 46578 Panlobular emphysema
H322.00 10980 Centrilobular emphysema
H32..00 794 Emphysema
H32y000 92955 Acute vesicular emphysema
H32y100 70787 Atrophic (senile) emphysema
H32y111 59263 Acute interstitial emphysema
H32y200 63479 MacLeod's unilateral emphysema
H32y.00 40788 Other emphysema
H32yz00 16410 Other emphysema NOS
H32z.00 33450 Emphysema NOS
H36..00 10863 Mild chronic obstructive pulmonary disease
H37..00 10802 Moderate chronic obstructive pulmonary disease
H38..00 9876 Severe chronic obstructive pulmonary disease
H39..00 93568 Very severe chronic obstructive pulmonary disease
H3A..00 104608 End stage chronic obstructive airways disease
H3...00 1001 Chronic obstructive pulmonary disease
H3...11 998 Chronic obstructive airways disease
H3y0.00 21061 Chronic obstruct pulmonary dis with acute lower resp infectn
H3y1.00 7884 Chron obstruct pulmonary dis wth acute exacerbation, unspec
H3y..00 12166 Other specified chronic obstructive airways disease
H3y..11 67040 Other specified chronic obstructive pulmonary disease
H3z..00 5710 Chronic obstructive airways disease NOS
H3z..11 37247 Chronic obstructive pulmonary disease NOS
H464000 64721 Chronic emphysema due to chemical fumes
H464100 63216 Obliterative bronchiolitis due to chemical fumes
H583200 106650 Eosinophilic bronchitis
Hyu3000 66058 [X]Other emphysema
Hyu3100 65733 [X]Other specified chronic obstructive pulmonary disease

Read terms are hierarhically organized in top-level chapters i.e. chapter G….00 is related to Circulatory System Diseases and sub-headings i.e. heading G2…00 is related to Hypertensive Heart Disease while G3…00 is related to Ischaemic Heart Disease.

Secondary Care

In Hospital Episode Statistics (HES, hospital admission data) we used ICD-10 terms (see below) for Chronic Obstructive Pulmonary Disease diagnosis when marked as the primary diagnosis i.e. the main condition treated or investigated during the relevant episode of healthcare. We used the date of admission to hospital as the date of the event. We additionally searched for OPCS-4 terms indicating the emergency repair of an aneurysmal segment of the aorta.

ICD10code ICD10codeDescr
J40 Bronchitis, not specified as acute or chronic
J41 Simple and mucopurulent chronic bronchitis
J42 Unspecified chronic bronchitis
J43 Emphysema
J44 Other chronic obstructive pulmonary disease


Combining evidence across sources to define and date phenotypes

At the specified date, a patient is defined as having had COPD IF they meet the criteria for any of the following on or before the specified date. The earliest date on which the individual meets any of the following criteria on or before the specified date is defined as the first event date:

Primary care
1. COPD diagnosis or history of diagnosis during a consultation 
Secondary care (ICD10)
1. ALL diagnoses of COPD or history of diagnosis during a hospitalization


  • Kuan V., Denaxas S., Gonzalez-Izquierdo A. et al. A chronological map of 308 physical and mental health conditions from 4 million individuals in the National Health Service published in the Lancet Digital Health - DOI 10.1016/S2589-7500(19)30012-3